Glyoxylic acid 50% MSDS

Glyoxylic acid  50%  MSDS

Section 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Production description: Glyoxylic acid 50 % (50 % aqueous solution)
Substance name: Glyoxylic acid
REACH Reg. No.: 01-2119487011-47-0001
Index No.: Not listed.
CAS No.: 298-12-4
EC No.: 206-058-5
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Use as Intermediate. Also used as material for methyl vanillin, ethyl vanillin in flavor industry.
Uses advised against: No uses advised against.
1.3 Details of the supplier of the SDS
 
Manufacturer: Zhonglan Industry Co.,ltd
Address: SANQING FENGRUN, BLDG, NO.100 SOUTH GONGYE ROAD, JINAN, CHINA
E-mail: info@zhognlanindustry.com
Telephone: +86-531-82956570
Fax: +86-531-82956571
Section 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008[CLP]
This substance is not classified in the Annex VI of Regulation (EC) No 1272/2008 as such.

Self-classifications according to Regulation (EC) No 1272/2008 criteria are as follows:

Corrosive to metals, hazard category 1; H290

Serious eye damage, hazard category 1; H318

Skin sensitisation, hazard category 1; H317

Classification according to Council Directive 67/548/EEC [DSD]
This substance is not classified in the Annex I of Directive 67/548/EEC as such.

Self-classifications according to Directive 67/548/EEC criteria are as follows:

Xi; R41  –  Xi; R43

Additional information
Full text of R-phrase(s) and H-statement(s): see section 16.
2.2 Label elements
  Labelling according to Regulation (EC) No 1272/2008 [CLP]
Production description: Gyoxylic acid 50 % (50 % aqueous solution)
Hazard pictogram(s):  

GHS05

 

GHS07

Signal word: Danger
Hazard statements: H290 May be corrosive to metals.

H317 May cause an allergic skin reaction.

H318 Causes serious eye damage.

Precautionary statements:
Prevention: P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response: P302 + P352 IF ON SKIN: Wash with plenty of soap and water.

P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Storage: P406 Store in corrosive resistant container with a resistant inner liner.
Disposal: P501 Dispose of contents/container in accordance with local/ regional/ national/ international regulations.
Supplemental Hazard information (EUH):
No information available.
Special rules for supplemental label elements for certain mixtures:
No information available.
  Labelling according to Directive 1999/45/EC
Symbol(s) and Indication(s) of Danger: Xi; Irritant
Risk Phrase: R41 – risk of serious damage to eyes.

R43 – may cause sensitisation by skin contact.

Safety Phrases: S26 – in case of contact with eyes, rinse immediately with plenty of water and seek medical advice

S28.1 – After contact with skin, wash immediately with plenty of water

S36/37/39 – wear suitable protective clothing, gloves and eye/face protection

2.3 Other hazards
  No information available.
 
Section 3: Composition/information on ingredients
3.1 Substance information
  Substance name CAS No. EC No. Index No. Classification according to DSD Classification according to CLP % (w/w)
Glyoxylic acid 298-12-4 206-058-5 Not listed. Xi; R41  –  Xi; R43 Met. Corr. 1; H290

Eye Dam. 1; H318

Skin Sens. 1; H317

≥ 50
Water 7732-18-5 231-791-2 Not listed. Not classified. Not classified. ≤ 48
Remark: The rest unspecified ingredients are impurities, and they do not influence classification and labeling of the product. Full text of R-phrase(s) and H-statement(s): see section 16.
Section 4: First aid measures
4.1 Description of first aid measures
  General notes: In all cases of doubt, or when symptoms persist, seek medical attention.
  Following inhalation:
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
  Following skin contact:
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.
  Following eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Continue rinsing eyes during transport to hospital.
  Following ingestion:
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Notes for the doctor:
Treat symptomatically and supportively.

Treatment may vary with condition of victim and specifics of incident.

4.2 Most important symptoms and effects, both acute and delayed
Potential Health Effects

Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract.

Skin May be harmful if absorbed through skin. Causes skin burns.

Eyes Causes eye burns.

Ingestion May be harmful if swallowed. Causes burns.

4.3 Indication of the immediate medical attention and special treatment needed
Persons with pre-existing skin, eye, or respiratory disease may be at increased risk from the irritant or allergic properties of this material. Attending physician should treat exposed patients symptomatically.
Section 5: Fire-fighting measures
5.1 Extinguishing media
  Suitable extinguishing media:
Dry chemical, carbon dioxide or water spray.
  Unsuitable extinguishing media:
Avoid direct contact between water and acid.
5.2 Special hazards arising from the substance or mixture
Substance is combustible. may burn but does not ignite readily.

Inspect the electrical fittings regularly against the higher risk of corrosion.

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Fire may produce irritating, corrosive and/or toxic gases.

5.3 Advice for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus.

In order to avoid contact with skin, keep a safety distance and wear suitable protective clothing.

Section 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.

Remove all sources of ignition. Evacuate personnel to safe areas.

Beware of vapours accumulating to form explosive concentrations.

Vapours can accumulate in low areas.

6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

6.3 Methods and material for containment and cleaning up
Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust)

Prevent product from entering drains.

Keep in suitable and closed containers for disposal.

Do not flush into surface water or sanitary sewer system.

6.4 Reference to other sections
See Section 7 for information on safe handling.

See section 8 for information on personal protection equipment.

See Section 13 for information on disposal.

Section 7: Handling and storage
7.1 Precautions for safe handling
Take care to maintain clean working place. Do not leave container open.

Use leak-proof equipment with exhaust for refilling or transfer.

Avoid spillage. Fill only into labelled container.

Use acid resistant utensils. Avoid any contact when handling the substance.

Avoid rising dust. Do not transport together with incompatible substances.

Use an appropriate exterior vessel when transporting in fragile containers.

7.2 Conditions for safe storage, including any incompatibilities
Store in the original container as much as possible.

Preferably use unbreakable containers rather than glass containers.

Place fragile vessels in break-proof outer vessels. Keep container tightly closed.

Recommended storage temperature: 2 to 8°.

Protect from overheating/heating up. Protect from moisture.

Substance is hygroscopic. Store under inert gas.

7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
Section 8 : Exposure controls/personal protection
8.1 Control parameters
  Occupational exposure limit values:
There are no currently occupational exposure limit values established for the substance.
  DNEL(Derived No Effect Level) for workers:
  Exposure pattern Route DNEL value Most sensitive endpoint
Long-term – systemic effects Dermal 4 mg/kg bw/day Repeated dose toxicity
Inhalation 9.4 mg/m³ Repeated dose toxicity
  DNEL(Derived No Effect Level) for the general population:
There are no DNEL values for the general population established for the substance.
  PNEC(Predicted No Effect Concentration) values:
There are no PNEC values established for the substance.
  Envirohnment compartment PNEC value
Aquatic compartment water(freshwater) 0.1 mg/l
water (marine water) 0.01 mg/l
sediment(freshwater) 0.374 mg/kg dw
sediment (marine water) 0.0374 mg/kg dw
Terrestrial compartment – Agricultural soil 0.0163 mg/kg
Terrestrial compartment – Grassland 0.0163 mg/kg
Sewage treatment plant 200 mg/l
Oral (secondary poisoning) No potential for bioaccumulation
8.2 Exposure controls
  Appropriate engineering controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
  Personal protective equipment:
Eye and face protection: Sufficient eye protection must be worn. Wear chemical safety goggles.

If the face is at risk as well as the eyes, a protective shield must also be worn.

Skin protection: Body protection:

Depending on the risk, wear a tight, long apron and boots or suitable chemical protection clothing. Wear dust tight protective clothing. The protection clothing should be acid resistant.

Hand protection:

Following data applies to concentrations up to 50%: The following materials are suitable for protective gloves (Permeation time ≥ 8 hours):

Natural rubber/Natural latex – NR (0.5 mm) (use non-powdered and allergen free products), Polychloroprene – CR (0.5 mm), Nitrile rubber/Nitrile latex – NBR (0.35 mm), Butyl rubber – Butyl (0.5 mm) , Fluoro carbon rubber – FKM (0.4 mm), Polyvinyl chloride – PVC (0.5 mm).

Respiratory protection: In an emergency (e.g.: unintentional release of the substance) respiratory protection must be worn. Consider the maximum period for wear.

At present time there is no available information about suitable filter respirator.

  Environmental exposure controls:
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

  Industrial hygiene:
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Section 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
  Appearance: Viscous liquid at 20 °C and 1013 hPa
  Colour: Colourless to yellowish
  Odour: Pungent
  pH: No information available.
  Melting point: Solidification at – 93 °C, softening at – 98 °C
  Boiling point: 111 °C at 1013 hPa
  Density: 1.34 g/cm³ at 19.5 °C
  Vapour pressure: 14 hPa at 20°C
  Surface tension: 56.3 +/- 0.5 mN/m at 25 °C
  Partition coefficient (n -octanol/water): Log Kow value of – 0.7 and – 1.4 for hydrated and anhydrous Glyoxylic Acid, respectively.
  Solubility(ies): 1 X 106 mg/l at 25°C.
  Flash point: There is no flash point up to the boiling point of 114 °C.
  Auto-ignition temperature: No data available.
  Flammability: Non flammable.
  Decomposition temperature: No data available.
  Explosive properties: Non explosive.
  Oxidising properties: No oxidising properties.
  Evaporation rate: No data available.
  Viscosity: 8.7 mPa*s at 25 °C
9.2 Other information
  No data available.
Section 10: Stability and reactivity
10.1 Reactivity
Can react with active metals to form gaseous hydrogen and a metal salt.

Reacts in this way with all bases, both organic (for example, the amines) and inorganic.

10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Flammable and/or toxic gases and heat are generated by the reaction with with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
10.4 Conditions to avoid
Incompatible materials.
10.5 Incompatible materials
Strong oxidizing agents, Strong bases, Metals.
10.6 Hazardous decomposition products
Carbon oxides, Formaldehyde.
Section 11: Toxicological information
11.1 Toxicokinetics, metabolism and distribution
  Glyoxylic Acid is a metabolic intermediate of ethylene glycol. Glyoxylic Acid 50% has no accumulation potential. Glyoxylic Acid is metabolised via a number of intermediate metabolic pathways. Glyoxylic Acid 50% is mainly excreted renally as parent compound or oxalic acid. Glyoxylic Acid was excreted to 16 % in respiratory CO2, 27.1 % as oxalic acid and 22 % as hippuric acid in the urine. (CSR)
11.2 Information on toxicological effects
  Acute toxicity:
Acute Oral toxicity: LD50 = 2528 mg/kg bw (rat) (CSR equivalent or similar to OECD Guideline 401);
Acute Inhalation toxicity: Quantitative data on the acute inhalation toxicity of this product are not available.
Acute Dermal toxicity: LC50 > 2000 mg/kg bw (rat) (CSR OECD Guideline 402);
  Skin corrosion/irritation:
Skin, rabbit: not irritating. (CSR OECD Guideline 404)
  Serious eye damage/irritation:
Eyes, rabbit: highly irritating. (CSR OECD Guideline 405)
  Respiratory or skin sensitization:
Local lymph node assay, mouse: sensitising. (CSR equivalent or similar to OECD Guideline 429)
  CMR effects (Carcinogenicity, Mutagenicity and Toxicity for Reproduction):
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Mutagenicity: Bacterial reverse mutation assay: negative. (CSR OECD Guideline 471)

Toxicity for reproduction: NOAEL: 600 mg/kg bw/day 

oral: feed; 2000, 6000 and 18000 ppm, 5 weeks (CSR OECD Guideline 422)

  STOT-single exposure and repeated exposure:
The product is not classified as specific target organ toxicant, single exposure, repeated exposure.
  Additional information:
RTECS # MD4550000
Section 12: Ecological information
12.1 Toxicity
Test material: glyoxylic acid
Acute toxicity to fish: LC50 > 200 mg/l/96h (Danio rerio)(CSR EU Method C.1, OECD Guideline 203);
Acute toxicity to daphnia: EC50 > 200 mg/l/48h (Daphnia magna)(CSR EU Method C.2, OECD Guideline 202);
Acute toxicity to algae: EC50 = 65.4 mg/l/72h (Scenedesmus capricornutum)(CSR OECD Guideline 201, EU Method C.3)
12.2 Persistence and degradability
Glyoxylic Acid 50% is readily biodegradable.
12.3 Bioaccumulative potential
A potential for bioaccumulation of Glyoxylic Acid 50% is not expected due to the log Pow of -0.7 (no B).

Glyoxylic Acid 50% is readily biodegradable. This indicates that the substance is not persistent. (CSR)

12.4 Mobility in soil
Based on best current information, there is no data known associated with this product.
12.5 Results of PBT and vPvB assessment
Glyoxylic Acid 50% does neither fulfil the PBT nor the vPvB criteria. (CSR)
12.6 Other adverse effects
No relevant information available.
Section 13: Disposal considerations
13.1 Waste treatment methods
Empty containers should be taken for local recycling, recovery or waste disposal. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material.
Section 14: Transport information
14.1 Land transport (ADR/RID/GGVSE)
UN-No.: 3265
Official transport designation: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Gyoxylic acid 50 %)
Class: 8
Classification Code: C3
Packing group: III
Hazard label: 8
14.2 Sea transport (IMDG-Code/GGVSee)
Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Gyoxylic acid 50 %)
Class: 8
UN-No.: 3265
Packing group: III
EmS No.: F-A, S-B
Marine pollutant: No
14.3 Air transport (ICAO-TI/IATA-DGR)
Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Gyoxylic acid 50 %)
Class: 8
UN-No.: 3265
Packing group: III
14.4 Additional information
No other information available.
Section 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
  EU regulation:
Authorisations: No information available.
Restrictions on use: No information available.
EINECS: CAS# 298-12-4 is listed in the inventory.
DSD (67/548/EEC): CAS# 298-12-4 is not listed in the Annex I.
  Other chemical regulation:
USA – TSCA: CAS# 298-12-4 is listed in the inventory.
Canada – DSL: CAS# 298-12-4 is listed in the inventory.
Australia – AICS: CAS# 298-12-4 is listed in the inventory.
Korea – ECL: CAS# 298-12-4 is listed in the inventory.
Japan – ENCS: CAS# 298-12-4 is listed in the inventory.
China – IECSC: CAS# 298-12-4 is listed in the inventory.
15.2 Chemical Safety Assessment
Chemical Safety Assessment has been carried out for this substance in accordance with REACH Article 14.
Section 16: Other information
16.1 Revision Information:
Date of the previous revision: Not applicable. Date of this revision: 25/02/2011.
Revision summary: The first new SDS
16.2 Abbreviations and acronyms
CLP: EU regulation (EC) No 1272/2008 on classification, labelling and packaging of chemical substances and mixtures.
CAS: Chemical Abstracts Service (division of the American Chemical Society).
EINECS: European Inventory of Existing Commercial Chemical Substances.
RID: European Rail Transport.
IMDG: International Maritime Code for Dangerous Goods.
IATA: International Air Transport Association.
OSHA: The United States Occupational Safety and Health Administration.
TSCA: Toxic Substances Control Act, The American chemical inventory.
DSD: Dangerous Substance Directive (67/548/EEC).
IECSC: Inventory of existing chemical substances in China.
DSL: Domestic Substances List, The Canadian chemical inventory.
AICS: The Australian Inventory of Chemical Substances.
ECL: Existing Chemicals List, the Korean chemical inventory.
ENCS: Japanese Existing and New Chemical Substances.
16.3 Key literature references and sources for data
ESIS IUCLID Dataset: European chemical Substances Information System.

CSR Chemical Safety Report of glyoxylic acid.

16.4 Relevant R-phrases and H-statements
R-phrases (code and full text):
R41 – risk of serious damage to eyes.

R43 – may cause sensitisation by skin contact.

H-statements (code and full text):
H290 May be corrosive to metals.

H317 May cause an allergic skin reaction.

H318 Causes serious eye damage.

16.5 Training advice
Provide adequate information, instruction and training for operators.
16.6 Declare to reader
The information in this Safety Data Sheet (SDS) was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This SDS was prepared and is to be used only for this product. If the product is used as a component in another product, this SDS information may not be applicable. According to REACH Article 31(5), the SDS shall be supplied in an official language of the Member State(s) where the substance or mixture is placed on the market, unless the recipient Member State(s) concerned provide otherwise. It should also be noted that this SDS is applicable to the countries with English as an official language.
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